Benefits and Side Effects of CBD Isolate

Cannabidiol in short as CBD is a phytocannabinoid extracted from cannabis plants, it accounts for up to 40% of the plant’s extract. Cannabidiol is used as smoke or vapor by inhalation, as an aerosol spray by mouth.  It is supplied as CBD isolate, CBD oil, capsules, dried cannabis, or prescription liquid solution.

CBD isolate is a crystalline or powdered form of CBD that contains 99% pure CBD. CBD isolate does not contain any traces of THC, the psychoactive component of cannabis which is present in other CBD products. CBD oil contains only CBD as the active ingredient (excluding tetrahydrocannabinol [THC] or terpenes), In the USA, Food and Drug Administration in 2018 has approved the cannabidiol drug Epidiolex for the treatment of two epilepsy disorders.


CBD isolate available at this website contains no measurable amounts of tetrahydrocannabinol, so it is free from psychoactive properties and will not intoxicate users. Tetrahydrocannabinol is responsible for the intoxicating effects of marijuana. CBD isolate interacts with the native endocannabinoid system and play a role in a number of physiological functions related to the central and peripheral nervous systems and the immune system.


CBD isolates works by interacting with the native endocannabinoid system, or ECS which is a large self-regulatory system, found in humans.

The endocannabinoid system is combination of several mechanisms and includes:

  • Enzymes responsible for creating and destroying cannabinoids
  • Receptor cannabinoids
  • endogenous Endocannabinoids.

In case of deviations from homeostasis (balance) in the body’s functions, the endocannabinoid system is activated and begins to respond by stimulating the synthesis of endocannabinoids, which act as neurotransmitters. The endocannabinoid systems include CB1 and CB2 receptor.

These Cannabinoid receptors are found on cells throughout the body. CB1 receptors are found primarily on the cells in the brain. CB2 receptors are highly concentrated on cells in the immune system.  2-arachidonoylglycerol (2-AG) and Anandamide (AEA) are two major endocannabinoids produced by the body.

When there is under stimulation of endocannabinoids CBD isolates mimic the behavior of endocannabinoids and interact with the cannabinoid receptors to augment the endocannabinoid system. CDB isolate interact with the cannabinoid receptors and stimulate various physiological responses. The stimulation of the endocannabinoid system through CBD’s isolate interaction with cannabinoid receptors in the brain supports greater balance and optimal functioning.


As CBD isolate does not contain THC it is generally a low-risk substance, but in some people, it may cause adverse reactions that include:

  •  increase or decrease in appetite
  • diarrhea
  • fatigue
  • weight loss or weight gain
  • insomnia
  • irritability

Taking CBD isolate medication with grapefruit or the supplements containing grapefruit should be avoided as it produces drug interactions and interfere with metabolism.